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  • 研究员
    郝立凯
    职  称: 研究员
    电  话: 15885542680
    邮  件: haolikai@mail.gyig.ac.cn
    地  址: 贵阳市观山湖区林城西路99号
    简历
    (1) 2016-11至现在, 中国科学院地球化学研究所, 环境地球化学国家重点实验室, 研究员 
    (2) 2011-04至2016-09, 图宾根大学, 应用地质中心, 研究助理 
    (3) 2009-03至2009-05, 哥本哈根大学, 微生物系, 访问学者 
    (4) 2009-01至2009-02, 马普海洋微生物研究所, 分子生态组, 访问学者 
    (5) 2007-07至2010-12, 厦门大学, 近海海洋环境科学国家重点实验室, 工程师
    研究方向
    1 微生物铁循环环境和生物化学机制 
    2 环境微生物组与重金属抗性组特征 
    3 植物-环境微生物组健康保障机制 4高级光电联用环境分析显微镜技术
    承担科研项目情况
    1 国家自然科学基金(41877400), 2019-2022,主持  
    2 中国科学院人才项目, 2017-2021,主持 
    3 科技部国家重点研发计划课题(2018YFC1802601), 2018-2022,主持 
    4 贵州省国家重点研发计划补助项目, 2021-2025,主持 
    5 中国科学院B类战略性先导专项课题(XDB40020300), 2020-2025,主要参加 
    6 中国科学院科技帮扶项目, 2022-2024,主要参加 
    7 德国 DFG Emmy-Noether项目, 2010-2015,结题,主要参加 
    8 欧盟第七框架计划(ERC307320-MICROFOX), 2007-2013 结题,主要参加 
    9 国家973计划(2004CB+2004CB619202), 2005-2012,结题,参加
    社会任职
    欧洲地球化学会会员 中国矿物岩石地球化学学会会员 中国化学会会员 中国旅德学者化学化工学会会员
    获奖及荣誉
    2021年度贵州省省管专家 
    2021年贵阳市生态环境专家 
    2014年度国家优秀自费留学生奖学金
    代表论著
    Likai Hao, Yuan Guo, James M. Byrne, Fabian Zeitvogel, Gregor Schmid, Pablo Ingino, Jianli Li, Thomas R. Neu, Elizabeth Swanner, Andreas Kappler, Martin Obst (2016).  Binding of heavy metal ions in aggregates of microbial cells, EPS and biogenic iron minerals measured in-situ using metal- and glycoconjugates-specific fluorophores. Geochimica et Cosmochimica Acta, 180, 66-96.
    Likai Hao, Jianli Li, Andreas Kappler, Martin Obst (2013). Mapping of heavy metal ion sorption to cell-extracellular polymeric substance-mineral aggregates by using, metal-selective fluorescent probes and confocal laser scanning microscopy. Applied and Environmental Microbiology 79(21), 6524-6534.
    Likai Hao, Yuan Guo, Na Jiang, Yang Li, Chengshuai Liu (2020). Confocal laser scanning microscopy and its application in Geobiology. Bulletin of Mineralogy, Petrology and Geochemistry 39 (6): 1141-1172.
    Likai Hao, Xiangmei Liu, Huiyan Wang, Jianqun Lin, Xin Pang, Jianqiang Lin (2012). Detection and validation of a small broad-host-range plasmid pBBR1MCS-2 for use in genetic manipulation of the extremely acidophilic Acidithiobacillus sp. Journal of Microbiological Methods 90(3): 309-314.
    Hui Yang, Xiankun Su, Li Cai, Zhenchun Sun, Yechun Lin, Jing Yu, Likai Hao, Cui Liu (2022a) Glutathione assisting the waste tobacco leaf to synthesize versatile biomass-based carbon dots for simultaneous detection and efficient removal of mercury ions. Journal of Environmental Chemical Engineering 10, 108718.
    Hui Yang, Yunlong Wei, Xiufang Yan, Chao Nie, Zhenchun Sun, Likai Hao, Xiankun Su (2022b) High-Efficiency Utilization of Waste Tobacco Stems to Synthesize Novel Biomass-Based Carbon Dots for Precise Detection of Tetracycline Antibiotic Residues. Nanomaterials 12, 3241.
    Xiaofeng Xie, Shangyi Gu, Likai Hao, Tianyi Zhang, Zidong Guo (2022). Rhizosphere microbial communities and geochemical constraining mechanism of antimony mine waste-adapted plants in southwestern China. Microorganisms. 
    Na Jiang, Yiqing Feng, Qiang Huang, Xiaoling Liu, Yuan Guo, Zhen Yang, Chao Peng, Shun Li, Likai Hao (2022). Effect of Environmental pH on Mineralization of Anaerobic Iron-oxidizing Bacteria. Frontiers in Microbiology, 1389 
    Peng Chen, Taotao Zhang, Yahui Chen, Haitao Ma, Yu Wang, Wei Liu, Yao Wang, Guangwu Zhou, Renwei Qing, Yun Zhao, Heng Xu, Likai Hao, Can Wang, Fei Xu (2022). Integrated Chamber-free Microbial Fuel Cell for Wastewater Purification and Bioenergy Generation. Chemical Engineering Journal 442, 136091 
    Xue-Yan Gao, Chang-Ai Fu, Li-Kai Hao, Xiu-Feng Gu,Rui Wang, Jian-Qiang Lin, Xiang-Mei Liu, Xin Pang, Cheng-Jia Zhang, Jian-Qun Lin, Lin-Xu Chen (2021). The substrate-dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles. Environmental Microbiology 23(2): 757-773. 
    Hui Tong, Chengshuai Liu, Likai Hao, Elizabeth D. Swanner, Manjia Chen, Fangbai Li, Yafei Xia, Yanan Liu, Yuhui Liu, Yanan Liu (2019). Biological Fe(II) and As(III) Oxidation Immobilizes Arsenic in Micro-oxic Environments. Geochimica et Cosmochimica Acta 265: 96-108.
    Fabian Zeitvogel, Gregor Schmid, Likai Hao, Pablo Ingino, Martin Obst (2016). ScatterJ: An ImageJ plugin for the evaluation of analytical microscopy datasets. Journal of Microscopy: 261(2): 148-156.
    Gregor Schmid, Fabian Zeitvogel, Likai Hao, Pablo Ingino, Irini Adaktylou, Merle Eickhoff, Martin Obst (2016). Submicron-scale heterogeneities in Nickel sorption of various cell-mineral aggregates formed by Fe(II)-oxidizing bacteria. Environ. Sci. Technol., 50 (1), 114–125
    Gregor Schmid, Fabian Zeitvogel, Likai Hao, Pablo Ingino, Wolfgang Kuerner, James J Dynes, Chithra Karunakaran, Jian Wang, Yingshen Lu, Travis Ayers, Chuck Schietinger, Adam P Hitchcock, Martin Obst (2014). Synchrotron-based chemical nano-tomography of microbial cell-mineral aggregates in their natural, hydrated state. Microscopy and Microanalysis 20 (2): 531-536.
    Gregor Schmid, Fabian Zeitvogel, Likai Hao, Pablo Ingino, Matthias Floetenmeyer, York-Dieter Stierhof, Birgit Schroeppel, Claus J. Burkhardt, Andreas Kappler, Martin Obst (2014). 3-D analysis of bacterial cell-(iron)mineral aggregates formed during Fe(II) oxidation by the nitrate-reducing Acidovorax sp. strain BoFeN1 using complementary microscopy tomography approaches. Geobiology 12 (4): 340–361.
    Elizabeth Swanner, Tim Bayer, Wenfang Wu, Likai Hao, Martin Obst, Anneli Sundman, James Byrne, F. Marc Michel, Andreas Kappler, Ronny Schoenberg (2017). Iron isotope fractionation during Fe(II) oxidation mediated by the oxygen-producing marine cyanobacterium Synechococcus PCC 7002. Environmental Science & Technology 51(9): 4897-4906.
    Wenfang Wu, Elizabeth D. Swanner, Likai Hao, Fabian Zeitvogel, Martin Obst, Yongxin Pan, Andreas Kappler (2014). Characterization of the physiology and cell-mineral interactions of the marine anoxygenic phototrophic Fe(II)-oxidizer Rhodovulum iodosum - implications for Precambrian Fe(II) oxidation. FEMS Microbiology Ecology 88 (3): 503–515.
    Elizabeth Swanner, Wenfang Wu, Likai Hao, Martin Obst, Mak Saito and Andreas Kappler (2015). Physiology, Fe(II) oxidation, and Fe mineral formation by a marine planktonic cyanobacterium grown under ferruginous conditions. Frontiers in Earth Science 3: 60.
    Zheng Yang, Likai Hao, Bing Yin, Mengyao She, Martin Obst, Andreas Kappler, Yifan Kang, Ping, Liu, Jianli Li, and Zhen Shi (2013). Six-membered spirocycle opening triggered fluorescent probe for visualizing Hg2+ in living cells and bacteria-EPS-mineral aggregates. Organic Letters 15(17): 4334-4337. Co-first author
    Xilang Jin, Likai Hao, Mengyao She, Martin Obst, Andreas Kappler, Jianli Li, Zhen Shi (2015). Visualizing tributyltin (TBT) in bacterial aggregates by specific rhodamine-based fluorescent probes. Analytica Chimica Acta 853(0): 514-520. Co-first author
    Zheng Yang, Mengyao She, Bing Yin, Likai Hao, Martin Obst, Ping Liu, and Jianli Li (2015). Solvent-dependent turn-on probe for dual monitoring of Ag+ and Zn2+ in living biological samples." Analytica Chimica Acta 868(0): 53-59
    Xilang Jin, Shaoping Wu, Mengyao She, Yifan Jia, Likai Hao, Bing Yin, Lanying Wang, Martin Obst, Yehua Shen, Yongmin Zhang, Jianli Li (2016). Novel Fluorescein-Based Fluorescent Probe for Detecting H2S and Its Real Applications in Blood Plasma and Biological Imaging. Analytical Chemistry  88 (22), 11253-11260 
    Xilang Jin, Likai Hao, Yanglin Hu, Mengyao She, Yanning Shi, Martin Obst, Jianli Li, Zhen Shi (2013).Two novel fluorescein-based fluorescent sensors for hypochlorite and its real applications in tap water and biological imaging. Sensors and Actuators B: Chemical 186(0): 56-60.
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